Manlio Di Stefano was born in Palermo, Sicily, in 1981.
After graduating in Computer Engineering, he worked as IT consultant for an American company. Meanwhile, he was a volunteer for an Italian NGO operating in the Democratic Republic of Congo and in Guatemala on projects related to sustainable development.
In 2013 he became a member of the Italian Parliament and he was appointed as group-leader for the Five Star Movement in the Foreign Affairs Committee for the entire legislature term.
Since 2013 he has been a member of the Italian delegation to the Council of Europe, as Chairperson of the Committee on Refugee and Migrant Children and Young People and he has successfully concluded and presented two reports on children's statelessness and unaccompanied migrant minors.
Since 2014 he has been the national supervisor for “LEX Parlamento”, one of the main tools included on the Five Star Movement’s web platform for e-democracy, called Rousseau.
In March 2018 he was re-elected member of the Italian Parliament and a few months later, on June 13th, he was appointed Undersecretary of State for Foreign Affairs.
On 16th September 2019 Undersecretary Di Stefano was reappointed with the same role in the Conte Government II.